Why gradual introduction acts as the bedrock for patient tolerability.
Why Precise Titration Matters
Starting with high doses immediately can overwhelm internal receptors, leading to severe flushing and discomfort.
Why Patients Often Struggle
Without a structured roadmap, patients frequently discontinue treatment prematurely due to unexpected physical reactions.
The Risk of Dose Dumping and Poor Patient Experience
Traditional immediate-release supplements cause rapid nutrient spikes, creating unstable physiological responses.
ENDUR-ACIN® ER The Clinical Foundation Of Our Solution
ENDUR-ACIN® ER helps maintain blood cholesterol and lipid levels within the normal range as shown in more than a dozen clinical trials, whether used alone or as a complement to other interventions.7,8
ENDUR-ACIN® ER helps maintain healthy lipoprotein(a) metabolism—an emerging biomarker of heart health.9
ENDUR-ACIN® ER promotes blood vessel tone and endothelial function (the ability of your blood vessels to dilate properly).10
ENDUR-ACIN® ER serves as a key building block for your body’s production of NAD+, a cellular energizer essential for metabolism that declines with age.11
SmartMatrix™ is the core delivery engine for an effective titration outcome. Our proprietary wax matrix core encases nutrients for guaranteed 6–8-hour delivery to the lower GI for optimal absorption and tissue retention*
ENDUR-ACIN® ER Titration Dosing Schedule
You'll start with a low dose, slowly increasing to a typical target dosage of 1,500 mg/day taken as two doses of 750 mg each - one in the morning and one in the evening.
Tips to Avoid Flushing
ENDUR-ACIN® ER is well tolerated. In clinical trials, only a few people (about 4 out of 100, on average) had side effects like flushing¹⁻⁶ However, you may experience temporary flushing, itching, or warmth on your skin when you start or increase niacin, but this usually doesn’t require discontinuing use. You can help reduce flushing by:
Avoiding hot beverages and vigorous exercise immediately after taking ENDUR-ACIN® ER.
Talking to your doctor about taking one aspirin (325 mg) with your first daily dose.
EndurPro™ has optimized processing. Simple, dependable, scales smoothly. Intuitive dosing graphic is trackable and intuitive.
Clinical Credibility & transformation story
Important Patient Instructions
Consult your doctor before starting or modifying any regimen
Do not chew or crush tablets
Take with food or with 2-3 full glasses of water (8 to 24 fluid ounces)
Avoid drinking excess alcohol to protect liver function
If you miss a dose, resume your usual schedule the next day (do not double up)
Do not use without the advice of your doctor if youhave poorly controlled diabetes, liver disease, gout, active peptic ulcer disease, or unstable angina
Store in a cool, dry place. Keep out of reach of children. Do not use if seal is broken or missing.
Dr. Bradley Bush is the Chief Medical Officer of Endurance Products Company and brings over 25 years of clinical and industry experience in integrative medicine.
❝ I regularly utilize this titration protocol in my practice to help patients transition successfully to a niacin regimen for improved cardiovascular health. ❞
The right dosing depends on your individual needs, so it’s important to follow your doctor’s instructions carefully. You’ll start with a low dose, slowly increasing to a typical target dosage of 1,500 mg/day taken as two doses of 750 mg each— one in the morning and one in the evening. This helps your body adjust to niacin and helps avoid skin flushing.