L-Arginine SR 350mg
L-Arginine SR 350mg
L-Arginine SR 350mg
L-Arginine SR 350mg
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L-Arginine SR 350mg

L-Arginine is a dietary supplement providing the amino acid L-arginine. The SmartMatrix™ sustained-release tablet is formulated for a slow, steady release of L-arginine over 4 to 6 hours to support heart and blood vessel health*.

  • No salt , starch, preservatives, artificial color or flavorings
  • Free of common allergens (milk, egg, fish, shellfish, tree nuts, peanuts, wheat and soy)
  • Convenient, easy-to-swallow tablets 

SmartMatrix™ is a trademark of Innovite , Inc.

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Product Info Sheet: Download Here
Clinical-Strength Formulation
SmartMatrix™ Sustained-Release
U.S. Manufactured, cGMP Certified

L-Arginine is specially formulated using SmartMatrix™sustained-releasetablet technology, resulting in a slow, steady release of l-arginine over 4to 6 hours. This gradual release promotes optimal absorption and tissueretention of l-arginine without the need to consume excessive amountstypically required with immediate-release forms.

L-Arginine is one of the body’s most metabolically versatile amino acids,supporting immune health, detoxification, proteinsynthesis, hormoneregulation, fertility, nitric oxide (NO) production, and more.L-Arginine supports blood vessel health and healthy endothelial functionprimarily by serving as a precursor for NO, which helps blood vessels relaxand supports blood pressure health. In addition, L-arginine has antioxidantproperties that may help protect blood vessels, Finally, it is reported tohelp modulate the renin-angiotensin-aldosterone system (RAAS), furthersupporting vascular health (1).

SuggestedUse: For adults, take three (3) tablets twice daily, preferablywith meals, or as directed by your healthcare practitioner.

Clean Formulas

No Preservatives

Gluten-free

Vegan Options

No Artificial Flavors

L-arginine supports endothelial function mainly by increasing NO production(2).

  • L-Arginine and Endothelial Function. One meta-analysis of 11 randomizedcontrolled trials (387 participants), found L-arginine supported optimalblood flow as measured by flow-mediated dilation (FMD) (3) Another meta-analysis of 13 randomized controlled trials (723 participants) reportedsimilar findings based on sensitivity analysis that excluded outlierstudies (4)
  • L-Arginine and Erectile Function. One systematic review and meta-analysisof 10 randomized control trials (540 participants) found L-argininesupports erectile function in men, an action attributed to its effect onNO production. NO activates guanylate cyclase, raising cGMP levels andrelaxing smooth muscle, which allows more blood flow for erection (5).

Arginine is converted into nitric oxide (NO) and citrulline in a two-stepreaction. Both steps are catalyzed by the same enzyme, nitric oxide synthase(NOS), which uses oxygen and NADPH as cofactors (2).

  1. Step 1-NOS converts arginine into an intermediate (N-hydroxy-l-arginine).
  2. Step 2-NOS converts thisintermediate into NO and citrulline.

Other Ingredients: Calcium phosphate, vegetable wax (rice bran and/orcarnauba wax), stearic acid (vegetable), magnesium stearate (vegetable), andsilica.

L-Arginineis manufactured inthe United States (Oregon) in a state-of-the-art, FDA-registered facility that meets or exceeds current Good ManufacturingPractices (cGMP). Quality control tests are performed at every stage of themanufacturing process from rigorous raw material testingto finished producttesting.

Precautions

Consult your healthcare professional prior to use if you have or suspect amedical condition, are taking any medications, or are pregnant or nursing

References

  1. Gambardella J, et al. Biomedicines. 2020;8(8):277.
  2. Stuehr DJ. Journal of Nutrition. 2004;134(10 Suppl):2748S–2767S.
  3. Bai Y, et al. American Journal of Clinical Nutrition. 2009;89(1):77–84
  4. Rodrigues-Krause J, et al. Nutrients. 2018;11(1):15.
  5. Rhim HC, et al. Journal of Sexual Medicine. 2019;16(2):223–234.

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Free Returns

within 30 days of purchase

Sustained Release

over 5–7 hours for lasting effect.