Pantethine from Pantesin® is a sustained-release dietary supplement featuring Pantesin® pantethine, a clinically validated form of pantethine. The SmartMatrix™ tablet ensures a slow, steady release over several hours for optimal absorption to promote heart, liver, and cholesterol health.*
Easy-to-swallow tablets
No salt, sugar, starch, artificial flavors, colors, sweeteners or preservatives
Gluten-free
Vegan/Vegetarian
Free of common allergens (milk, egg, fish, shellfish, soy, peanuts, tree nuts and wheat)
SmartMatrix is a trademark of Innovite, Inc. PANTESIN® is a registered trademark of Daiichi Fine Chemical Co., Ltd.
Pantethine features Pantesin® pantethine, a high-purity, highly absorbable form backed by clinical research and over 30 years of safe and effective use in Japan for heart health. The SmartMatrix™ sustained-release tablet allows for a slow, steady release over several hours for optimal absorption.
Pantethine is the stable disulfide form of pantetheine, the metabolic substrate that forms the active part of coenzyme A (CoA) and acyl carrier proteins (ACP). The key functional group in both is the sulfhydryl (SH)moiety donated from cysteine. Unlike pantothenic acid (vitamin B5), pantethine supplies the essential SH group for enzyme activity, making it a more metabolically active form. CoA is a cofactor in over 70 enzymatic pathways, including fatty acid oxidation and acetylation in phase II detoxification. ACP is an essential component of the fatty acid synthase complex, required for fatty acid elongation (1).
Research indicates pantethine may help maintain blood cholesterol and lipid levels within the normal range, and its actions complement alternative therapies that support cardiovascular health (2).
Suggested Use: Take one (1) tablet with morning and evening meals, or as directed by your healthcare practitioner.
Clean Formulas
No Preservatives
Gluten-free
Vegan Options
No Artificial Flavors
Supports Cholesterol & Lipid Balance. One systematic review of 28 clinical trials indicates pantethine exerts consistent and significant effects on the body’s ability to support healthy cholesterol metabolism and lipid balance. The median dose of pantethine was 900 mg/day with a range of 600 to 1,200 mg/day. The average duration of interventions was about 4 months, indicating a gradual effect (3). Others report similar benefits with 600-900 mg/day for 16 weeks (2,4).
Supports Phase II Detoxification. Pantethine, as a precursor to coenzyme A(CoA), supports phase II detoxification by aiding acetylation reactions(5). In these liver-based reactions, acetyl-CoA transfers an acetyl group to a pesticide, environmental pollutant, or other xenobiotic, making the more water-soluble so they can be excreted from the body instead of stored in fat (6).
The Pantesin® Advantage
High Quality. A high-purity, highly absorbable form of pantethine.
Research-Backed. Backed by more than 35 years of clinical research.
Excellent Safety Profile. Side effects uncommon & generally mild (e.g., temporary digestive upset).
Other Ingredients: Vegetable wax (rice bran and/or carnauba), cellulose, stearic acid (vegetable), magnesium stearate (vegetable), and silica.
Pantethine from Pantesin® is manufactured in the United States (Oregon) in a state-of-the-art, FDA-registered facility that meets or exceeds current Good Manufacturing Practices (cGMP). Quality control tests are performed at every stage of the manufacturing process from rigorous raw material testing to finished product testing.
Precautions
Consult your healthcare professional prior to use if you have or suspect a medical condition, are taking any medications, or are pregnant or nursing.
References
Anonymous. Altern Med Rev. 2010;15(3):279-282.
Evans M, et al. Vasc Health Risk Manag. 2014;10:89-100.
McRae MP. Nutr Res. 2005;25:319-333.
Rumberger JA, et al. Nutr Res. 2011;31(8):608-615.
