PepZinGI® Zinc-Carnosine features a clinically validated zinc-carnosinechelate that helps fortify the protective mucous membrane lining the stomach and intestines.
PepZinGI® is a unique chelate in which zinc is bound to the dipeptide L-carnosine, forming a stable complex. It has been used for decades in Japan to promote the health and integrity of the stomach mucosal lining and support gastric health. Its unique form allows it to remain stable in stomach acid and adhere to mucosa, where it gradually releases zinc and L-carnosine. The key mechanisms of action include:
--Helps stabilize cells membranes, supporting mucosal integrity
--Scavenges free radicals and supports antioxidant enzyme activity, lowering oxidative stress
--Helps modulate the body’s natural inflammatory response
--Helps stimulate protective proteins like heat shock proteins, aiding cell protection
The gastric health effects of PepZinGI® are independent of acid reduction as it does not suppress gastric acid secretion or alter prostaglandin E2levels.L-carnosine is metabolized locally and does not enter the bloodstream, while zinc is absorbed with minimal impact on overall zinc levels (1)
Directions: As a dietary supplement, take or chew one (1) tablet, twice daily with or without meals, or as directed by your healthcare practitioner.
Clean Formulas
No Preservatives
Gluten-free
Vegan Options
No Artificial Flavors
PepZinGI® is clinically validated to support GI mucosal health
Supports Intestinal Mucosal Integrity. One double-blind, placebo-controlled, crossover study indicates that PepZinGI® helps support and stabilize the mucosal lining in the small intestine and is well tolerated(2). Dosage: 37.5 mg, twice daily.
Supports Stomach Mucosal Integrity. One multi-center, double-blind study indicates that PepZinGI® helps support and stabilize the mucosal lining in the stomach and is well tolerated (3). Dosage: 75 mg, twice daily.
Promotes Digestive Comfort. One multi-center, double-blind, controlled study indicates that PepZinGI® supports digestive comfort, helps maintain the integrity of the stomach mucosa, and is well tolerated (4). Dosage: 75mg, twice daily.
PepZinGI® Zinc-Carnosine is the only zinc L-carnosine that has undergone an FDA review for safety and human use, resulting in New Dietary Ingredient(NDI) status for adults and children over 12.
--Adults and children over 12: Maximum daily intake is 150 mg/day (providing34 mg elemental zinc).
--Elderly: Reduce maximum daily intake to less than 100 mg due to reduced digestive function.
--Children under 12, pregnant and lactating women: Not recommended due to lack of safety data.
This added measure of regulatory oversight further supports PepZinGI® as a trusted option for your clinical practice.
Other Ingredients: Isomalt (vegetable), stearic acid (vegetable), magnesium stearate (vegetable), modified cellulose (vegetable), and silica.
PepZin GI® Zinc L-Carnosineis manufactured in the United States (Oregon) in a state-of-the-art, FDA-registered facility that meets or exceeds current Good Manufacturing Practices (cGMP). Quality control tests are performed at every stage of the manufacturing process from rigorous raw material testing to finished product testing.
Precautions
Consult your healthcare professional prior to use if you have or suspect a medical condition, are taking any medications, or are pregnant or nursing.
References
Efthymakis K, et al. Clinical Research in Hepatology and Gastroenterology. 2022;46(7):101954.
Mahmood A, et al. Gut. 2007;56(2):168–175.
Miyoshi A, et al. Japanese Pharmacology & Therapeutics. 1992;20(1):199–223
Nakajima M, et al. Japanese Pharmacology & Therapeutics. 1997;25(4):325–366.
