Plain Niacin 500mg
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Plain Niacin 500mg

Plain Niacin features immediate-release nicotinic acid. The SmartMatrix ™ tablet dissolves more slowly than regular immediate-release formulas, gradually releasing nicotinic acid in just under one hour rather than all at once. It's a low-flush option to promote heart health and cholesterol balance.*

  • Easy-to-swallow tablets
  • No salt, sugar, starch, artificial flavors, colors, sweeteners or preservatives
  • Gluten-free
  • Vegan/Vegetarian
  • Free of common allergens (milk, egg, fish, shellfish, soy, peanuts, tree nuts and wheat) 
  • Immediate release (1 hour)
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Product Info Sheet: Download Here
Clinical-Strength Formulation
SmartMatrix™ Sustained-Release
U.S. Manufactured, cGMP Certified

Plain Niacin combines immediate-release nicotinic acid (also known as crystalline niacin) with our proprietary SmartMatrix™ vegetable-based wax-matrix tablet. The tablet dissolves in just under one hour rather than all at once, which helps reduce excess skin flushing and digestive upset typical of regular formulas.

Nicotinic acid is the only form of niacin specifically associated with heart health benefits. Its cardiovascular effects result from both lipid-based and non-lipid mechanisms (see Research Highlights).

It’s important to note that so-called “flush-free” forms of niacin may reduce flushing, but these forms have not been clinically shown to benefit heart health.

Note: Immediate-release and extended-release nicotinic acid products are not interchangeable. The typical therapeutic dosage for immediate-release nicotinic acid (3,000 to 6,000 mg/day in divided doses) is substantially higher than that for extended-release tablets (1,500 to 2,000 mg/day in divided doses).

Directions: As a dietary supplement for adults, take one (1) tablet daily with food. Do not exceed one tablet daily without consulting a physician.

Clean Formulas

No Preservatives

Gluten-free

Vegan Options

No Artificial Flavors

Lipid Actions. The ability of nicotinic acid to support cardiovascular health is attributed to several lipid-related actions. For example, nicotinic acid may help maintain the following lipid-based parameters (2):

May help maintain:

  • healthy LD L cholesterol levels†
  • healthy triglyceride levels†
  • healthy HDL cholesterol levels†
  • healthy lipoprotein metabolism
  • healthy LDL particle size distribution
  • healthy apolipoprotein A - 1 levels†

†already within the normal range.

Non-Lipid Actions. Nicotinic acid may offer non-lipid support via its antioxidant capacity and ability to help modulate the body’s natural anti-inflammatory response (2).

May help maintain:

  • healthy vascular function (2-4)
  • healthy vascular inflammatory response (2)
  • healthy LDL oxidation balance (2)
  • the body’s natural antioxidant defenses (5)
  • healthy blood vessel wall integrity (6)
  • healthy endothelial function (6)

Niacin (as nicotinic acid or niacinamide) is essential for numerous biochemical functions that contribute to whole body health and health aging (7,8):

  • Supports cellular energy. Niacin is a precursor for NAD+, essential for mitochondrial energy production and ATP generation.
  • Supports fat, hormone, and bioactive compound production. Niacin activates enzymes involved in synthesizing fatty acids, steroids, hormones, and other bioactive molecules.
  • Promotes energy release from foods. Niacin is required to activate over 200 enzymes in carbohydrate, fat, and protein metabolism.
  • Supports skin, nerve, and digestive health. Niacin helps maintain healthy skin, mucous membranes, and digestive tract, and supports nervous system function.
  • Promotes DNA repair and cell division. Niacin (via NAD+) supports enzymes that maintain DNA health and influence gene stability and expression.

Other Ingredients: Isomalt, vegetable wax (rice bran and/or carnauba),stearic acid (vegetable), magnesium stearate (vegetable), silica, cellulose.

Plain Niacin (Nicotinic Acid) is manufactured in the United States (Oregon)in a state-of-the-art, FDA-registered facility that meets or exceeds current Good Manufacturing Practices (cGMP). Quality control tests are performed at every stage of the manufacturing process from rigorous raw material testing to finished product testing.

Precautions

Consult your healthcare professional prior to use if you have or suspect a medical condition, are taking any medications, or are pregnant or nursing. Temporary flushing, itching or warming of the skin may occur. Do not use without the advice of your physician if you consume more than modest amounts of alcohol, have poorly controlled diabetes, liver disease, gout, active peptic ulcer disease, or unstable angina.

References

  1. Keenan J. The Niacin Breakthrough. Joseph Keenan MD; 2022.
  2. Kamanna VS, et al. Am J Cardiol. 2008;101(8A):20B-26B.
  3. Li Y, Yang G, et al. J Nutr Biochem. 2015;26(11):1338-1347.
  4. Wu BJ, et al. Circulation. 2012;125(1):150-158.
  5. Ganji SH, et al. Atherosclerosis. 2009;202(1):68-75.
  6. Bruckert E, et al. Atherosclerosis. 2010;210(2):353-361.
  7. Ross AC, et al. Modern Nutrition in Health and Disease. 11th ed. Lippincott Williams & Wilkins; 2014:331-340.
  8. Srivastava S, et al. Clin Transl Med. 2016;5(1):25.

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Sustained Release

over 5–7 hours for lasting effect.