ENDUR-ACIN® ER Patient Starter Kit is a clinically validated niacin titration program designed to help patients comfortably adapt to niacin supplementation while supporting cardiovascular health.*
Powered by proprietary SmartMatrix™ sustained-release technology, niacin is delivered gradually over 6–8 hours to provide steady nutrient release while helping reduce flushing and improve tolerability.*
The starter kit includes both 250 mg and 500 mg tablets and follows a structured four-week dosing schedule developed to support patient comfort and compliance.
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Clinical-Strength Formulation
SmartMatrix™ Sustained-Release
U.S. Manufactured, cGMP Certified
Clinically validated titration program
SmartMatrix™ sustained-release technology
Gradual niacin delivery over 6–8 hours
Supports healthy cholesterol metabolism*
Supports healthy triglyceride balance*
Supports healthy lipoprotein (Lp(a)) metabolism*
Supports healthy blood vessel function*
Helps reduce niacin flushing*
Easy-to-swallow tablets
Gluten-free
Vegan/Vegetarian
Free of common allergen
ENDUR-ACIN® ER Patient Starter Kit provides a clinically validated introduction to niacin therapy through a four-week titration schedule utilizing both 250 mg and 500 mg tablets.
Using SmartMatrix™ sustained-release technology, niacin is delivered gradually over 6–8 hours, helping promote patient comfort while supporting cardiovascular wellness and healthy lipid metabolism.
Follow the Patient Starter Kit titration schedule:
Week 1
250 mg daily
Week 2
500 mg daily
Week 3
500 mg daily
Week 4
750 mg daily
Adults should take tablets with food or as directed by a healthcare professional.
Adults seeking nutritional support for:
Healthy cholesterol metabolism
Healthy triglyceride balance
Healthy lipoprotein (Lp(a)) metabolism
Healthy blood vessel function
Cardiovascular wellness
Clean Formulas
No Preservatives
Gluten-free
Vegan Options
No Artificial Flavors
Unlike conventional niacin supplements that release rapidly, SmartMatrix™ technology gradually delivers niacin over several hours.
Niacin (vitamin B3) has been extensively studied for its role in supporting healthy lipid metabolism and cardiovascular health. Emerging evidence suggests niacin supports healthy cholesterol transport, blood vessel function, and lipoprotein metabolism through multiple physiological pathways.
ENDUR-ACIN® ER utilizes proprietary SmartMatrix™ technology that gradually releases niacin over approximately 6–8 hours, helping reduce the rapid plasma concentration spikes commonly associated with immediate-release niacin products.
The result is sustained nutrient delivery designed to support cardiovascular wellness while improving patient tolerability and adherence.
ENDUR-ACIN® ER is manufactured in the United States (Oregon) in a state-of-the-art, FDA-registered facility that meets or exceeds current Good Manufacturing Practices (cGMP).
Quality control testing is performed throughout every stage of manufacturing, including raw material verification, in-process testing, and finished product testing.
Frequently Asked Questions
ENDUR-ACIN® ER provides sustained-release niacin delivery designed to support cardiovascular health while helping reduce flushing and improve patient comfort.*
SmartMatrix™ sustained-release technology gradually releases niacin over approximately 6–8 hours, providing steady nutrient delivery and improved tolerability.*
One bottle of ENDUR-ACIN® ER 250 mg (45 tablets)
One bottle of ENDUR-ACIN® ER 500 mg (45 tablets)
Total: 90 tablets (30-day supply)
Consult your healthcare professional before use if you have a medical condition, are taking medication, are pregnant, planning to become pregnant, or nursing.
Precautions
Consult your healthcare professional prior to use if you have or suspect a medical condition or are taking any medications. Do not use in combination with carbidopa, or any drug, supplement, or herb with serotonergic or sedative properties, without consulting your healthcare professional. Do not use if you are pregnant or nursing, under the age of 18 years, or have scleroderma. This product may cause drowsiness or mild, transient digestive upset. Discontinue use and consult a doctor if any adverse reactions occur. Discontinue use at least 2 weeks before elective surgery
References
Maffei ME. International Journal of Molecular Sciences. 2020;22(1):181.
Turner EH, et al. Pharmacology & Therapeutics. 2006;109(3):325–338.
Sutanto CN, et al. Clinical Nutrition. 2024;43(3):593–602.
Xie X, et al. Synthetic and Systems Biotechnology. 2022;7(1):544–553.
